Lophiile shows how resampling audio, not processing it with plugins, creates textures you can't get any other way. He runs through a few practical moves for melodic material.
On a piano line, he doubles the playback speed and pitches it up an octave, then uses a tape-style re-pitch mode to bring it back down. The result sounds more sampled, more lo-fi, more real, because the high end gets muted in a way that mimics tape.
For a synth layer, he freezes the audio, prints it to a new track, and shifts it up an octave using a different pitch algorithm than the original. Blending that resampled layer back in adds thickness and character a MIDI-only approach can't match.
He also prints a melodic line, reverses it, and mixes that reversed layer underneath the original. It's a simple trick, but layering forward and backward versions of the same part creates movement and depth that straight processing won't give you.